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Cocaine Causes Women’s Periods to Go Out of Phase; Caffeine Restores It

12/25/2014

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In a recently published article, titled "Cocaine Shifts the Estrus Cycle Out of Phase and Caffeine Restores It" published by the Journal of Caffeine Research, Patricia Broderick, PhD and Lauren Malave, City College of New York and NYU Langone Medical Center, New York, NY, show that cocaine shifts the estrus cycle, thereby changing a woman's estrogen levels. Caffeine can block these changes, suggesting that antagonists of the adenosine system may have a role in treating cocaine addiction.

One of their study’s conclusions is that cocaine's ability to disrupt a woman's period may explain the sex differences in cocaine addiction. It also presents new evidence that caffeine may be neuroprotective and able to block cocaine's direct effects on the estrus cycle. This could reveal novel treatment possibilities according to the authors.

In this video, Dr. Brandi Nichols, Women's Clinic of JCMG, explains the parameters of a normal period:
The abstract of the article is below, along with a link to it.

Background: Sex differences in cocaine abuse are well established. Females have a higher sensitivity and thus higher vulnerability to cocaine abuse compared to males. There are many studies showing that sensitivity to cocaine reward varies during the estrus cycle.

Methods: Vaginal smears were examined through a DIFF staining kit and viewed through a microscope to determine the estrus cycle stage. Smears were taken immediately before and after cocaine and/or caffeine injections. Furthermore, we suggest a new tool to analyze the estrus cycle by using electrical resistance of the vaginal mucosa.

Results: In the present study, we discovered that cocaine directly induced changes in the estrus cycle. Interestingly, caffeine did not affect the estrus cycle and nor did the combination of cocaine and caffeine. We observed that caffeine blocked the cocaine-induced estrus cycle changes using conventional exfoliate cytology. Therefore, caffeine may have neuroprotective properties on the changes induced by cocaine.

Conclusion: These phase changes in the estrus cycle may be the underlying cause of sex differences in cocaine addiction that can be blocked by caffeine. Thus, we propose a valuable insight into sex differences in cocaine abuse and reveal a possible treatment with antagonizing the adenosine system.

Link:  Cocaine Shifts the Estrus Cycle Out of Phase and Caffeine Restores It

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How to Make Your Dunkin Donut Extreme

12/12/2014

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No, this is not an ad from Dunkin Donut… of those my fave is still the one they ran some thirty years back, with that funny, slightly overweight franchise owner, doubling as the pastry maker,  slaving away at 2 am….

No, this is December 2014, with DD "owning" the breakfast trade and who knows what else. Making tons of those doughnuts, doughnut holes, croissants, bagels, etc. in the wee hours of the night certainly have paid off!

But look… somebody is upstaging the master pastry maker… sprinkling a liberal amount of CaffeinAll on their chocolate covered doughnuts. About 200-300 mg of it from the looks of it…. 

Picture

Horror of horrors… so DD’s coffee is not strong enough? 

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